Among them, diacylglycerol activates PKC and impairs IRS-1 activation, while ceramides activate protein kinase C zeta (PKC) and protein phosphatase 2A (PP2A), resulting in dephosphorylation of Akt, 31,32 and promoting gluconeogenesis
Furthermore, TNF- affects the expression of the GPX4 protein and regulates the potential ferroptosis state of cells
Phytomedicine 10:7479 Shen X, Shi H, Chen X, Han J, Liu H, Yang J, Shi Y, Ma J (2023) Esculetin alleviates inflammation, oxidative stress and apoptosis in intestinal ischemia/reperfusion injury via targeting SIRT3/AMPK/mTOR signaling and regulating
Journal of Plastic Surgery and Hand Surgery
This suggests that many reported candidate biomarkers were either highly dependent on technical considerations, or represent false positives due to unaccounted confounders